The antidiabetic effects of Paullinia pinnata root bark

Paullinia pinnata root bark has been found to contain antidiabetic effects. A study published in the Journal of Complementary and Integrative Medicine investigated the phytochemical composition, antidiabetic, oral glucose tolerance test, and antioxidant activities of P. pinnata root bark extract.

• P. pinnata has been used in folk medicine to manage diabetic-related conditions.
• Researchers from the Michael Okpara University of Agriculture in Abia State Umuahia, Nigeria induced diabetes in mice by administering alloxan at the dose of 160 milligrams per kilogram (mg/kg).
• Then, the now diabetic mice received glibenclamide or 50, 100, or 200 mg/kg of P. pinnata root bark extract.
• The researchers saw that P. pinnata root bark extract contains alkaloids, flavonoids, glycosides, tannins, saponins, and sterols.
• The results of the study also revealed that P. pinnata root bark extract significantly reduced the fasting blood glucose levels in treated mice.
• P. pinnata root bark extract also caused a significant oral glucose tolerance effect in mice.
• Moreover, the extract exhibited a concentration-dependent increase in antioxidant activity.

In conclusion, the findings of the study suggest that P. pinnata root bark has strong antidiabetic and antioxidant properties, confirming its use in folk medicine.

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Journal Reference:

Okwudili OS, Chimaobi NG, Ikechukwu EM, Ndukaku OY. ANTIDIABETIC AND IN VITRO ANTIOXIDANT EFFECTS OF HYDROMETHANOL EXTRACT OF PAULLINIA PINNATA ROOT BARK IN ALLOXAN-INDUCED DIABETIC RAT. Journal of Complementary and Integrative Medicine. 17 November 2017; 15(2). DOI: 10.1515/jcim-2015-0017